Categoría: Oncology & Cancer
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Hidden blood mutations linked to higher heart disease risk after cancer treatment
About one in five patients with cancer who undergo genetic testing are incidentally found to have mutations in their blood called clonal hematopoiesis of indeterminate potential (CHIP). A study by Vanderbilt Health researchers reveals that it puts them…
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Study links dozens of blood proteins to prostate cancer risk across populations
A large-scale study has identified dozens of blood proteins linked to prostate cancer risk, some shared across populations, some unique to specific groups.
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Targeting epigenetic modifiers and splicing regulators together may offer new acute myeloid leukemia treatment paths
Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations—IDH2 and SRSF2—work cooperatively to mis-splice RNA messages and change how blood cells develop.
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For the first time, a mechanism enabling breast cancer to metastasize to the brain has been deciphered
A large-scale international study, led by researchers from the Gray Faculty of Medical and Health Sciences at Tel Aviv University, has uncovered a mechanism that allows breast cancer to send metastases to the brain—a highly lethal occurrence for which …
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Retrotransposon drives cancer by altering 3D genome structure
Scientists at St. Jude Children’s Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation. Retrotransposons are mobile DNA pieces, comprising much of the human …
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How a rare genetic variant protects some people from developing blood cancers
Blood cancer is an umbrella term for a variety of diseases that affect the blood, bone marrow and lymphatic system. Like most cancers, the cause is usually mutations in the DNA, which are genetic errors that accumulate as we age. However, some people a…
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Study finds a better way to screen for breast cancer
A pioneering study has found that an individualized approach to breast cancer screening that assesses patients’ risk, rather than annual mammograms, can lower the chance of more advanced cancers, while still safely match people to the amount of screeni…
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Rb1 identified as predictive biomarker for new therapeutic strategy in some breast cancers
A new study published in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center details a therapeutic vulnerability in patients with an aggressive subtype of triple-negative breast cancer.
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BRAF gene mutation leads to different therapeutic responses in melanoma and colorectal cancer
A review article led by researchers from the B·ARGO group at the Germans Trias i Pujol Research Institute (IGTP) and from the Medical Oncology Department of the Catalan Institute of Oncology (ICO) in Badalona provides a comparative analysis of the impa…
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Open-source software sheds light on cancer’s hidden genetic networks
University of Navarra (Spain) researchers have developed RNACOREX, a new open-source software capable of identifying gene regulation networks with applications in cancer survival analysis.