Categoría: Oncology & Cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and b…

Using lung cancer biospecimens from the Sherlock-Lung study, an international team led by National Institutes of Health (NIH) researchers, identified key factors that drive tumor evolution and influence outcomes. Overall, the findings, published in Nat…

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

A team of researchers at the Icahn School of Medicine at Mount Sinai has uncovered why children with the same leukemia-causing gene mutation can have dramatically different outcomes: It depends on when in development the mutation first occurs.

Even as they develop at their primary site, pancreatic cancer cells are already expressing the genes that will determine where they will metastasize, according to new findings from Columbia researchers. The work, published in Nature Genetics, reveals a…

Cancer isn’t just about broken genes—it’s about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services. That’s what happens inside cells when the 3D structure of DNA collapses.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable bacterial product causes mutations in DNA that have been linked to colorectal cancer. Because it breaks down quickly, isolating…

The order of cancer-driving mutations—genetic changes—plays an important role in whether tumors in the intestine can develop, new research reveals.

A Northwestern Medicine study published in the Journal of Clinical Investigation has uncovered a connection between a well-known cancer-related protein and a major RNA modification process, which may inform new treatment strategies against prostate can…

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in cancer and identified cancer-driving mutations in an underexplored part of the genome.