Autor: Jun Fu

Expanding the clinical and mutational spectrum of hereditary spastic paraplegia type 4 in a cohort of patients from central China

Mar 30, 2026

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por

Jun Fu

en Articulos, Enfermedades Raras, Frontiers in Genetics, Original Research

BackgroundMutations in the SPAST gene cause autosomal dominant hereditary spastic paraplegia (HSP) type 4 (SPG4), which is the most common type of HSP with variable frequencies in different ethnic backgrounds. The clinical and genetic characteristics o…