Autor: Genetics News – Genetics Science, Genetics Technology, Genetics
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Cancer’s hidden ‘safety switch’: Silencing TAK1 gene could boost immunotherapy performance
Australian researchers have discovered that the TAK1 gene helps cancer cells survive attack from the immune system, revealing a mechanism that may limit the effectiveness of immunotherapy treatments.
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Subtyping colorectal cancer may improve patient outcome predictions
Colorectal cancer, or CRC, is the world’s second most lethal cancer based on the number of deaths, and is the third most prevalent malignant tumor. Doctors and patients have long been hoping for better diagnostics for prognosis, such as molecular subty…
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Hidden ‘switches’ in DNA reveal new insights into Alzheimer’s disease
A tiny percentage of our DNA—around 2%—contains 20,000-odd genes. The remaining 98%—long known as the non-coding genome, or so-called ‘junk’ DNA—includes many of the «switches» that control when and how strongly genes are expressed.
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Is aging an act of genetic sabotage? Scientists find a gene that turns off food detection after reproduction
When roundworms stop reproducing, they can still move and function normally but lose their ability to detect certain food odors that once led them to their meals.
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Genetic influences on health can ripple through social groups via shared microbes
Your «roommate’s» genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published in Nature Communications.
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Individual genetic differences can render some antibody-based therapies ineffective
Antibody-based therapies are used to treat numerous diseases, from cancer to rheumatic disorders and multiple sclerosis. Antibodies recognize and bind to very specific structures. This allows them to direct active substances to exactly the right target…
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‘Molecular glue’ stabilizes protein that inhibits development of non-small cell lung cancer
Lung cancer is the second-most common cancer and the leading cause of cancer death in the United States. Over 80% of lung cancers are non-small cell lung cancers, in which tumor cells are larger and grow more slowly than those in small cell lung cancer.
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How disabling one gene protects mice against Type 1 diabetes
Scientists at the University of Wisconsin–Madison have uncovered a possible way to protect key cells in the pancreas that are targeted during the development of Type 1 diabetes.
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Gene therapy advances as scientists guide jumping DNA to target faulty genes
JABSOM Cell and Molecular Biology researcher Dr. Jesse Owens has spent the better part of two decades chasing a vision that began with the revolutionary idea that DNA can move itself. Now, his team’s latest breakthrough is published in Nucleic Acids Re…
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New details on role of fat transport molecules in Alzheimer’s onset
A new study presents robust evidence on the role of lysophosphatidylcholines (LPCs) in the onset of Alzheimer’s disease. Researchers discovered that LPCs—compounds that transport a variety of healthy fatty acids to the brain—either promote Alzheimer’s …
