Autor: Genetics News – Genetics Science, Genetics Technology, Genetics
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Personalizing cancer treatments significantly improves outcomes in clinical trial
Researchers at University of California San Diego School of Medicine have led the first clinical trial in the world to show that cancer drug treatments can be safely and effectively personalized based on the unique DNA of a patient’s tumor.
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Most Alzheimer’s cases linked to variants in a single gene
Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.
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Genetic study uncovers unknown causes of blindness
Researchers from Radboud University Medical Center and University of Basel have discovered new genetic causes of inherited blindness. Their study, published in Nature Genetics, shows that changes in specific pieces of DNA, which play a role in processi…
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Shared genes may influence both artery calcification and bone density
A new study published suggests that the connection between coronary artery calcification—a measure of calcium buildup in the arteries—and bone mineral density may be driven in part by shared genetic factors, rather than one directly causing the other. …
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Disaster-related prenatal maternal stress has epigenetic outcomes
Maternal prenatal stress related to natural and human-made disasters can lead to epigenetic modifications in offspring, according to a recent narrative review.
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How major nuclear protein complexes control specialized gene regulation in cancer and beyond
Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein complexes—that control gene expression locate to speci…
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Short-circuiting pancreatic cancer: A potential RNA therapy
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It’s also the most common form of the disease. Potential treatments typically target a key mutated oncogene called KRAS. In some cases, PDAC tumors with these mutations…
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Mapping proteins in African genomes reveals new paths to fight type 2 diabetes
Researchers have conducted the most comprehensive analysis to date linking plasma proteins to genetic variation in individuals from continental Africa. Their study addresses a long-standing gap by studying a population grossly underrepresented in medic…
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Study links dozens of blood proteins to prostate cancer risk across populations
A large-scale study has identified dozens of blood proteins linked to prostate cancer risk, some shared across populations, some unique to specific groups.
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Genomics uncovers new ways to target chronic childhood disease
Mapping the genomes of the bacteria responsible for yaws, a debilitating childhood disease, has uncovered new insights into how these bacteria re-emerge and evade treatment.