{"id":8560,"date":"2026-01-20T16:00:00","date_gmt":"2026-01-20T16:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=845d5d7fe742d91b71f894f339a0ef9f"},"modified":"2026-01-20T23:00:00","modified_gmt":"2026-01-20T23:00:00","slug":"a-gene-specific-variance-control-approach-corrects-polygenicity-driven-inflation-observed-in-transcriptome-wide-association-studies","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/01\/20\/a-gene-specific-variance-control-approach-corrects-polygenicity-driven-inflation-observed-in-transcriptome-wide-association-studies\/","title":{"rendered":"A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies"},"content":{"rendered":"We show that transcriptome-wide association studies (TWAS) and related methods (xWAS) using genetic predictors suffer from inflated false-positive rates for highly polygenic complex traits, increasing linearly with sample size and heritability. We propose a variance-control method that yields well-calibrated results when applied to both simulated and real data.","protected":false},"excerpt":{"rendered":"<p>We show that transcriptome-wide association studies (TWAS) and related methods (xWAS) using genetic predictors suffer from inflated false-positive rates for highly polygenic complex traits, increasing linearly with sample size and heritability. We prop&#8230;<\/p>\n","protected":false},"author":403,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-8560","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/403"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=8560"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8560\/revisions"}],"predecessor-version":[{"id":8908,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8560\/revisions\/8908"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=8560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=8560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=8560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}