{"id":8548,"date":"2026-02-05T16:00:00","date_gmt":"2026-02-05T16:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=62f00d3938f33a7a90e9b3b79b151c0e"},"modified":"2026-02-05T23:00:00","modified_gmt":"2026-02-05T23:00:00","slug":"mendelian-randomization-linking-metabolites-with-enzymes-reveals-pathway-regulation-and-therapeutic-avenues","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/02\/05\/mendelian-randomization-linking-metabolites-with-enzymes-reveals-pathway-regulation-and-therapeutic-avenues\/","title":{"rendered":"Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues"},"content":{"rendered":"Mendelian randomization (MR) is widely used to identify causality between human traits; however, it suffers from high error rates. Van der Graaf et al. benchmark MR using human metabolic networks to understand MR\u2019s failure modes. Extensive biological follow-up reveals that up to 43% of MR positives have plausible literature support.","protected":false},"excerpt":{"rendered":"<p>Mendelian randomization (MR) is widely used to identify causality between human traits; however, it suffers from high error rates. Van der Graaf et al. benchmark MR using human metabolic networks to understand MR\u2019s failure modes. Extensive biological f&#8230;<\/p>\n","protected":false},"author":400,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-8548","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/400"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=8548"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8548\/revisions"}],"predecessor-version":[{"id":8902,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8548\/revisions\/8902"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=8548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=8548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=8548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}