{"id":8088,"date":"2025-11-04T16:00:00","date_gmt":"2025-11-04T16:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=1cbf2728a81343e0107e00684a546712"},"modified":"2025-11-04T23:00:00","modified_gmt":"2025-11-04T23:00:00","slug":"histencode-a-proposed-project-to-decipher-functional-interactions-among-and-between-histone-ptms","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/11\/04\/histencode-a-proposed-project-to-decipher-functional-interactions-among-and-between-histone-ptms\/","title":{"rendered":"HistENCODE: a proposed project to decipher functional interactions among and between histone PTMs"},"content":{"rendered":"Twenty-five years after the histone code hypothesis proposed that combinations of histone post-translational modifications (PTMs) direct gene regulation, fundamental questions remain unresolved. Here, I outline a call for a multi-laboratory initiative, termed HistENCODE, to systematically decipher functional relationships between histone PTMs via direct mutagenesis of histone N-terminal tail residues.","protected":false},"excerpt":{"rendered":"<p>Twenty-five years after the histone code hypothesis proposed that combinations of histone post-translational modifications (PTMs) direct gene regulation, fundamental questions remain unresolved. Here, I outline a call for a multi-laboratory initiative,&#8230;<\/p>\n","protected":false},"author":389,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,65],"tags":[79],"class_list":["post-8088","post","type-post","status-publish","format-standard","hentry","category-articulos","category-trends-in-genetics","tag-trendsgen"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/389"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=8088"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8088\/revisions"}],"predecessor-version":[{"id":8154,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/8088\/revisions\/8154"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=8088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=8088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=8088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}