{"id":612,"date":"2024-02-11T19:40:23","date_gmt":"2024-02-11T19:40:23","guid":{"rendered":"http:\/\/sebgc.es\/blog\/?guid=66e6d53f2ab354f2064060c01480a33d"},"modified":"2024-02-11T19:40:23","modified_gmt":"2024-02-11T19:40:23","slug":"the-prevalence-and-linkage-disequilibrium-of-21-genetic-variations-related-to-thrombophilia-folate-cycle-and-hypertension-in-reproductive-age-women-of-rostov-region-russia","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2024\/02\/11\/the-prevalence-and-linkage-disequilibrium-of-21-genetic-variations-related-to-thrombophilia-folate-cycle-and-hypertension-in-reproductive-age-women-of-rostov-region-russia\/","title":{"rendered":"The prevalence and linkage disequilibrium of 21 genetic variations related to thrombophilia, folate cycle, and hypertension in reproductive age women of Rostov region (Russia)"},"content":{"rendered":"\n<h2>Abstract<\/h2>\n<p>Several maternal genetic variations are known to play an important role during pregnancy since they can affect mother health and\/or fetal growth. The frequency of these variants is variable among different populations. This study aimed to investigate thrombophilia, folate metabolism and hypertension genetic variants in reproductive age women of Rostov region (Russia) and then assess their linkage disequilibrium (LD) and heterogeneity among populations. A total of 3108 reproductive age women were included (33.75\u00a0\u00b1\u00a05.13 years). Twenty-one genetic variants were detected with RT-PCR. LD was tested according to (D\u2032) coefficient and <i>p<\/i> value. The highest frequency of mutant allele in studied population was as follows: <i>PAI-1<\/i> rs1799768, <i>MTRR<\/i> rs1801394, <i>AGT<\/i> rs699, and <i>AGTR2<\/i> rs1403543. We showed a high possibility of coinheritance of <i>MTHFR<\/i> rs1801133 with rs1801131 and <i>AGT<\/i> rs699 with rs4762 (D\u2032=0.992 and 0.999, respectively). In addition, comparative analysis showed <i>F7<\/i> rs6046, <i>FGB<\/i> rs1800790, <i>MTR<\/i> rs1805087, and <i>AGT<\/i> rs699 significantly more frequent among Rostov females by 1.3\u20131.5 times than European. <i>MTHFR<\/i> rs1801133, <i>ADD1<\/i> rs4961, <i>AGTR2<\/i> rs1403543, <i>NOS3<\/i> rs2070744, and rs1799983 were with higher frequencies in Europeans than those in the studied group. Our data could be used as a reference for further associative studies of targeted genetic variations in different pregnancy complications specifically in this population.<\/p>","protected":false},"excerpt":{"rendered":"<p>Annals of Human Genetics, Volume 88, Issue 2, Page 171-181, March 2024.<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40,6,42],"tags":[43],"class_list":["post-612","post","type-post","status-publish","format-standard","hentry","category-annual-review-of-genomics-and-human-genetics","category-articulos","category-original-article","tag-annhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=612"}],"version-history":[{"count":1,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/612\/revisions"}],"predecessor-version":[{"id":613,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/612\/revisions\/613"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}