{"id":5488,"date":"2025-12-19T23:00:00","date_gmt":"2025-12-19T23:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=629a6f36b86f249c6e50b5d864f3dce5"},"modified":"2025-12-19T23:00:00","modified_gmt":"2025-12-19T23:00:00","slug":"mirage-a-bayesian-statistical-method-for-gene-level-rare-variant-analysis-incorporating-functional-annotations","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/12\/19\/mirage-a-bayesian-statistical-method-for-gene-level-rare-variant-analysis-incorporating-functional-annotations\/","title":{"rendered":"MIRAGE: A Bayesian statistical method for gene-level rare-variant analysis incorporating functional annotations"},"content":{"rendered":"In this paper, we proposed a computational Bayesian method\u2014MIRAGE\u2014to perform rare-genetic-variant analysis in population-matched case-control studies or transmitted variants from families. Several plausible autism-risk genes are identified by applying MIRAGE to whole-exome-sequencing data, offering insight into the mechanisms of autism.","protected":false},"excerpt":{"rendered":"<p>In this paper, we proposed a computational Bayesian method\u2014MIRAGE\u2014to perform rare-genetic-variant analysis in population-matched case-control studies or transmitted variants from families. Several plausible autism-risk genes are identified by applying &#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-5488","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5488"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5488\/revisions"}],"predecessor-version":[{"id":5489,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5488\/revisions\/5489"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}