{"id":5478,"date":"2025-12-23T23:00:00","date_gmt":"2025-12-23T23:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=4548a63a711df918ef3392419bbe95e1"},"modified":"2025-12-23T23:00:00","modified_gmt":"2025-12-23T23:00:00","slug":"msh3-is-a-genetic-modifier-of-somatic-repeat-instability-in-x-linked-dystonia-parkinsonism","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/12\/23\/msh3-is-a-genetic-modifier-of-somatic-repeat-instability-in-x-linked-dystonia-parkinsonism\/","title":{"rendered":"MSH3 is a genetic modifier of somatic repeat instability in X-linked dystonia parkinsonism"},"content":{"rendered":"MSH3 modifies both age of onset and the somatic instability of the X-linked dystonia parkinsonism hexanucleotide repeat. This highlights a critical role of somatic instability in driving disease, highlights MSH3 as a human-validated therapeutic target, and underscores somatic instability as a common mechanism among repeat expansion disorders.","protected":false},"excerpt":{"rendered":"<p>MSH3 modifies both age of onset and the somatic instability of the X-linked dystonia parkinsonism hexanucleotide repeat. This highlights a critical role of somatic instability in driving disease, highlights MSH3 as a human-validated therapeutic target,&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-5478","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5478","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5478"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5478\/revisions"}],"predecessor-version":[{"id":5479,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5478\/revisions\/5479"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5478"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5478"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5478"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}