{"id":5472,"date":"2026-01-08T23:00:00","date_gmt":"2026-01-08T23:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=aad8ba75946c6140d042d0047df71c49"},"modified":"2026-01-08T23:00:00","modified_gmt":"2026-01-08T23:00:00","slug":"lima-robust-inference-of-molecular-mediation-from-summary-statistics","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/01\/08\/lima-robust-inference-of-molecular-mediation-from-summary-statistics\/","title":{"rendered":"LiMA: Robust inference of molecular mediation from summary statistics"},"content":{"rendered":"LiMA and its random-effect variant I-LiMA infer molecular mediation in a Mendelian randomization framework using summary statistics. Jointly modeling direct and mediated effects while accounting for measurement error, they reduce weak-instrument bias and false positives in simulations. Applications to real data reveal metabolites and proteins mediating obesity-related cardiometabolic risk.","protected":false},"excerpt":{"rendered":"<p>LiMA and its random-effect variant I-LiMA infer molecular mediation in a Mendelian randomization framework using summary statistics. Jointly modeling direct and mediated effects while accounting for measurement error, they reduce weak-instrument bias a&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-5472","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5472"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5472\/revisions"}],"predecessor-version":[{"id":5473,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5472\/revisions\/5473"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}