{"id":5470,"date":"2026-01-08T23:00:00","date_gmt":"2026-01-08T23:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=4283dc644e03478cd32c7df6db028378"},"modified":"2026-01-08T23:00:00","modified_gmt":"2026-01-08T23:00:00","slug":"this-month-in-the-journal-4","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/01\/08\/this-month-in-the-journal-4\/","title":{"rendered":"This month in The Journal"},"content":{"rendered":"We often describe the functional effects of genetic variants using terms such as \u201closs of function\u201d or \u201cgain of function.\u201d These terms have an origin in Muller\u2019s morphs, a classification system published almost a hundred years ago. At that time, the structure of DNA and proteins were not known, and the interconnectedness of signaling pathways had not been discovered. While Muller\u2019s morphs can still successfully categorize variants with a single effect, many complex variants do not fit into one of those boxes.","protected":false},"excerpt":{"rendered":"<p>We often describe the functional effects of genetic variants using terms such as \u201closs of function\u201d or \u201cgain of function.\u201d These terms have an origin in Muller\u2019s morphs, a classification system published almost a hundred years ago. At that time, the st&#8230;<\/p>\n","protected":false},"author":258,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-5470","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/258"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5470"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5470\/revisions"}],"predecessor-version":[{"id":5471,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5470\/revisions\/5471"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}