{"id":5468,"date":"2026-01-08T23:00:00","date_gmt":"2026-01-08T23:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=ccb54911ff33b6b9eb1e954ed26171c2"},"modified":"2026-01-08T23:00:00","modified_gmt":"2026-01-08T23:00:00","slug":"functional-analysis-of-npr2-variants-supports-the-therapeutic-rationale-for-cnp-in-short-stature","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/01\/08\/functional-analysis-of-npr2-variants-supports-the-therapeutic-rationale-for-cnp-in-short-stature\/","title":{"rendered":"Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature"},"content":{"rendered":"Loss-of-function variants in NPR2 are associated with short-stature disorders. A high-throughput GFP reporter assay classified functional activity of NPR2 missense variants, revealing a near-linear association between activity level and standing height, demonstrating the potential value in modulating NPR2 in short-stature conditions.","protected":false},"excerpt":{"rendered":"<p>Loss-of-function variants in NPR2 are associated with short-stature disorders. A high-throughput GFP reporter assay classified functional activity of NPR2 missense variants, revealing a near-linear association between activity level and standing height&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-5468","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5468"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5468\/revisions"}],"predecessor-version":[{"id":5469,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5468\/revisions\/5469"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}