{"id":533,"date":"2024-01-10T19:00:00","date_gmt":"2024-01-10T19:00:00","guid":{"rendered":"http:\/\/sebgc.es\/blog\/?guid=23ade5c5268bb2725f220d0ae109e1bc"},"modified":"2024-01-10T23:00:00","modified_gmt":"2024-01-10T23:00:00","slug":"a-comprehensive-analysis-of-clinical-and-polygenic-germline-influences-on-somatic-mutational-burden","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2024\/01\/10\/a-comprehensive-analysis-of-clinical-and-polygenic-germline-influences-on-somatic-mutational-burden\/","title":{"rendered":"A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden"},"content":{"rendered":"We investigated how genetic and non-genetic host characteristics influence the accumulation of both somatic point mutations and copy number variants. We found fine-scale genetic ancestry and polygenic risk scores were associated with tumor mutational burden. We additionally found that many of these associations impacted overall survival.","protected":false},"excerpt":{"rendered":"<p>We investigated how genetic and non-genetic host characteristics influence the accumulation of both somatic point mutations and copy number variants. We found fine-scale genetic ancestry and polygenic risk scores were associated with tumor mutational b&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-533","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=533"}],"version-history":[{"count":4,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/533\/revisions"}],"predecessor-version":[{"id":657,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/533\/revisions\/657"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}