{"id":521,"date":"2024-01-18T19:00:00","date_gmt":"2024-01-18T19:00:00","guid":{"rendered":"http:\/\/sebgc.es\/blog\/?guid=1d733696ed7f68438d28e994ccb3aa5b"},"modified":"2024-01-18T23:00:00","modified_gmt":"2024-01-18T23:00:00","slug":"the-shared-ancestry-between-the-c9orf72-hexanucleotide-repeat-expansion-and-intermediate-length-alleles-using-haplotype-sharing-trees-and-haptk","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2024\/01\/18\/the-shared-ancestry-between-the-c9orf72-hexanucleotide-repeat-expansion-and-intermediate-length-alleles-using-haplotype-sharing-trees-and-haptk\/","title":{"rendered":"The shared ancestry between the C9orf72 hexanucleotide repeat expansion and intermediate-length alleles using haplotype sharing trees and HAPTK"},"content":{"rendered":"Using haplotype sharing trees and majority-based ancestral haplotypes, we demonstrate that the C9orf72 hexanucleotide repeat expansion and alleles with \u226518\u201320 repeats share large haplotype blocks, indicating very recent shared ancestry. This was in sharp contrast to the shorter alleles, suggesting that expansions might be formed from the longer repeat alleles.","protected":false},"excerpt":{"rendered":"<p>Using haplotype sharing trees and majority-based ancestral haplotypes, we demonstrate that the C9orf72 hexanucleotide repeat expansion and alleles with \u226518\u201320 repeats share large haplotype blocks, indicating very recent shared ancestry. This was in sha&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-521","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=521"}],"version-history":[{"count":4,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/521\/revisions"}],"predecessor-version":[{"id":651,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/521\/revisions\/651"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}