{"id":5201,"date":"2025-09-10T15:00:00","date_gmt":"2025-09-10T15:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=c79aa852e0a9810edcab5bd8d7193307"},"modified":"2025-09-10T23:00:00","modified_gmt":"2025-09-10T23:00:00","slug":"unmasked-transposable-elements-as-drivers-and-targets-in-cancer","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/09\/10\/unmasked-transposable-elements-as-drivers-and-targets-in-cancer\/","title":{"rendered":"Unmasked: transposable elements as drivers and targets in cancer"},"content":{"rendered":"Transposable elements (TEs) \u2013 long considered \u2018junk DNA\u2019 \u2013 challenge the binary of threat and therapeutic opportunity in cancer. Their reactivation is not a singular event but a convergence of evolutionary legacy, regulatory disruption, and technological insight. This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state. Across regulatory control, viral mimicry, protein-coding potential, and antigen presentation, TEs blur the line between harm and utility. Each example reflects a broader theme: context defines consequence. By tracing historical shifts and technological advances, we argue for an integrated view: one where TEs are not just anomalies, but dynamic agents in the complexity of cancer.","protected":false},"excerpt":{"rendered":"<p>Transposable elements (TEs) \u2013 long considered \u2018junk DNA\u2019 \u2013 challenge the binary of threat and therapeutic opportunity in cancer. Their reactivation is not a singular event but a convergence of evolutionary legacy, regulatory disruption, and technologic&#8230;<\/p>\n","protected":false},"author":333,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,65],"tags":[79],"class_list":["post-5201","post","type-post","status-publish","format-standard","hentry","category-articulos","category-trends-in-genetics","tag-trendsgen"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/333"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=5201"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5201\/revisions"}],"predecessor-version":[{"id":5390,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/5201\/revisions\/5390"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=5201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=5201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=5201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}