{"id":3595,"date":"2025-11-18T18:00:00","date_gmt":"2025-11-18T18:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=b7ef54f69e2785fa4d4d9b4eeb4b4571"},"modified":"2025-11-18T23:00:00","modified_gmt":"2025-11-18T23:00:00","slug":"bi-allelic-prmt9-loss-of-function-variants-cause-a-syndromic-form-of-intellectual-disability","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/11\/18\/bi-allelic-prmt9-loss-of-function-variants-cause-a-syndromic-form-of-intellectual-disability\/","title":{"rendered":"Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability"},"content":{"rendered":"Bi-allelic loss-of-function variants in protein arginine methyltransferase 9 (PRMT9) cause a neurodevelopmental disorder with variable severity. Affected individuals have mild to severe intellectual disability, global developmental delay, autism spectrum disorder, epilepsy, and hypotonia. Functional studies on patients\u2019 cells reveal a possible functional impact on ciliary functions.","protected":false},"excerpt":{"rendered":"<p>Bi-allelic loss-of-function variants in protein arginine methyltransferase 9 (PRMT9) cause a neurodevelopmental disorder with variable severity. Affected individuals have mild to severe intellectual disability, global developmental delay, autism spectr&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-3595","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=3595"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3595\/revisions"}],"predecessor-version":[{"id":3740,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3595\/revisions\/3740"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=3595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=3595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}