{"id":3577,"date":"2025-12-04T18:00:00","date_gmt":"2025-12-04T18:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=c3095fd4471e9da436fe732b1f4fbee9"},"modified":"2025-12-04T23:00:00","modified_gmt":"2025-12-04T23:00:00","slug":"functional-classification-of-platelet-gene-variants-using-crispr-hdr-in-cd34-cell-derived-megakaryocytes","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/12\/04\/functional-classification-of-platelet-gene-variants-using-crispr-hdr-in-cd34-cell-derived-megakaryocytes\/","title":{"rendered":"Functional classification of platelet gene variants using CRISPR HDR in CD34+ cell-derived megakaryocytes"},"content":{"rendered":"Using CRISPR-edited CD34+ cells differentiated into megakaryocytes, CRIMSON HD models Glanzmann thrombasthenia phenotypes, providing a robust, lineage-relevant framework for functional testing and reclassification of clinically ambiguous variants in inherited platelet disorders.","protected":false},"excerpt":{"rendered":"<p>Using CRISPR-edited CD34+ cells differentiated into megakaryocytes, CRIMSON HD models Glanzmann thrombasthenia phenotypes, providing a robust, lineage-relevant framework for functional testing and reclassification of clinically ambiguous variants in in&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-3577","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=3577"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3577\/revisions"}],"predecessor-version":[{"id":3731,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/3577\/revisions\/3731"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=3577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=3577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=3577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}