{"id":16212,"date":"2026-04-22T15:00:00","date_gmt":"2026-04-22T15:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=1aa34b9193f6f958ad2483a6e0eb0702"},"modified":"2026-04-22T23:00:00","modified_gmt":"2026-04-22T23:00:00","slug":"evaluation-of-chimerism-testing-by-next-generation-sequencing-using-indel-markers-analytical-validation-and-examples-of-clinical-utilization","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/04\/22\/evaluation-of-chimerism-testing-by-next-generation-sequencing-using-indel-markers-analytical-validation-and-examples-of-clinical-utilization\/","title":{"rendered":"Evaluation of chimerism testing by next generation sequencing using indel markers: Analytical validation and examples of clinical utilization"},"content":{"rendered":"Post-transplant engraftment monitoring is essential to assess the risk of complications after allogeneic hematopoietic transplantation such as graft failure and disease relapse. It is based on the analysis of the percentage of chimerism detected in the recipient. Chimerism analysis has been routinely performed using short tandem repeats (STR). Next generation sequencing (NGS) has made possible the use of other genetic markers such as single nucleotide polymorphisms (SNPs) and insertions\/deletions (indels).","protected":false},"excerpt":{"rendered":"<p>Post-transplant engraftment monitoring is essential to assess the risk of complications after allogeneic hematopoietic transplantation such as graft failure and disease relapse. It is based on the analysis of the percentage of chimerism detected in the&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,54],"tags":[55],"class_list":["post-16212","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-journal-of-molecular-diagnostics","tag-jmoldiagn"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=16212"}],"version-history":[{"count":12,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16212\/revisions"}],"predecessor-version":[{"id":16385,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16212\/revisions\/16385"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=16212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=16212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=16212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}