{"id":16180,"date":"2026-04-22T11:00:00","date_gmt":"2026-04-22T11:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=0cda4a5ef99bfca4804268e912815597"},"modified":"2026-04-22T23:00:00","modified_gmt":"2026-04-22T23:00:00","slug":"clinical-grade-somatic-variant-interpretation-performance-via-a-rule-constrained-large-language-model-framework-olive","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/04\/22\/clinical-grade-somatic-variant-interpretation-performance-via-a-rule-constrained-large-language-model-framework-olive\/","title":{"rendered":"Clinical-Grade Somatic Variant Interpretation Performance via a Rule-Constrained Large Language Model Framework (OLIVE)"},"content":{"rendered":"Interpretation of somatic variants in clinical oncology requires integration of gene-specific biology, tumor context, and multiple evidence sources. While large language models (LLMs) can assist variant interpretation, concerns remain regarding reproducibility, safety, and dependence on opaque model behavior. We developed and evaluated a rule-constrained LLM-based decision support framework, OLIVE (Oncology Logic-Informed Variant Evaluator), for somatic variant interpretation in a clinical molecular pathology service.","protected":false},"excerpt":{"rendered":"<p>Interpretation of somatic variants in clinical oncology requires integration of gene-specific biology, tumor context, and multiple evidence sources. While large language models (LLMs) can assist variant interpretation, concerns remain regarding reprodu&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,54],"tags":[55],"class_list":["post-16180","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-journal-of-molecular-diagnostics","tag-jmoldiagn"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=16180"}],"version-history":[{"count":13,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16180\/revisions"}],"predecessor-version":[{"id":16386,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/16180\/revisions\/16386"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=16180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=16180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=16180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}