{"id":14798,"date":"2026-03-23T15:00:00","date_gmt":"2026-03-23T15:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=522bbfcf31918e10fe0728d1eed371ca"},"modified":"2026-03-23T23:00:00","modified_gmt":"2026-03-23T23:00:00","slug":"grin2a-one-gene-many-phenotypes","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/03\/23\/grin2a-one-gene-many-phenotypes\/","title":{"rendered":"GRIN2A: one gene, many phenotypes"},"content":{"rendered":"GRIN2A, a gene encoding a subunit of the N-methyl-d-aspartate (NMDA) receptor, is linked to epilepsy, language impairment, and schizophrenia, but how these associations relate to one another within individuals remains unclear. Recontacting GRIN2A carriers shows that loss-of-function variants are associated with psychiatric risk not captured in earlier ascertainment of the same cohort, highlighting how study design shapes observed gene\u2013disease relationships.","protected":false},"excerpt":{"rendered":"<p>GRIN2A, a gene encoding a subunit of the N-methyl-d-aspartate (NMDA) receptor, is linked to epilepsy, language impairment, and schizophrenia, but how these associations relate to one another within individuals remains unclear. Recontacting GRIN2A carri&#8230;<\/p>\n","protected":false},"author":533,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,65],"tags":[79],"class_list":["post-14798","post","type-post","status-publish","format-standard","hentry","category-articulos","category-trends-in-genetics","tag-trendsgen"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/533"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=14798"}],"version-history":[{"count":23,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14798\/revisions"}],"predecessor-version":[{"id":15327,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14798\/revisions\/15327"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=14798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=14798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=14798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}