{"id":14082,"date":"2026-04-02T17:00:00","date_gmt":"2026-04-02T17:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=09f86ddff81884e22059d4bc9a51e18d"},"modified":"2026-04-02T23:00:00","modified_gmt":"2026-04-02T23:00:00","slug":"associations-of-genetic-variants-with-gene-expression-factors-reveal-biological-pathways-underlying-complex-traits","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/04\/02\/associations-of-genetic-variants-with-gene-expression-factors-reveal-biological-pathways-underlying-complex-traits\/","title":{"rendered":"Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits"},"content":{"rendered":"GWASs have identified thousands of trait-associated variants, yet their downstream mechanisms remain unclear. By linking variants to pathway-level expression factors and developing the effect consistency test, we uncover biological pathways mediating immune trait associations, providing a new framework to connect genetic variation with phenotypic effects.","protected":false},"excerpt":{"rendered":"<p>GWASs have identified thousands of trait-associated variants, yet their downstream mechanisms remain unclear. By linking variants to pathway-level expression factors and developing the effect consistency test, we uncover biological pathways mediating i&#8230;<\/p>\n","protected":false},"author":523,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-14082","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/523"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=14082"}],"version-history":[{"count":22,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14082\/revisions"}],"predecessor-version":[{"id":14177,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/14082\/revisions\/14177"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=14082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=14082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=14082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}