{"id":1301,"date":"2025-09-30T02:00:00","date_gmt":"2025-09-30T02:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=a6901504ffb198fec8a4e26d69086ac7"},"modified":"2025-09-30T23:00:00","modified_gmt":"2025-09-30T23:00:00","slug":"a-cardiovascular-craniofacial-and-neurodevelopmental-disorder-caused-by-loss-of-function-variants-in-the-eif3-complex-component-genes-eif3a-and-eif3b","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/09\/30\/a-cardiovascular-craniofacial-and-neurodevelopmental-disorder-caused-by-loss-of-function-variants-in-the-eif3-complex-component-genes-eif3a-and-eif3b\/","title":{"rendered":"A cardiovascular, craniofacial, and neurodevelopmental disorder caused by loss-of-function variants in the eIF3 complex component genes EIF3A and EIF3B"},"content":{"rendered":"Loss-of-function variants in EIF3A and EIF3B can lead to a variable multisystem congenital disorder, primarily involving cardiac anomalies, craniofacial differences, and mild neurodevelopmental features. These findings are supported by an international clinical cohort and zebrafish mutant models.","protected":false},"excerpt":{"rendered":"<p>Loss-of-function variants in EIF3A and EIF3B can lead to a variable multisystem congenital disorder, primarily involving cardiac anomalies, craniofacial differences, and mild neurodevelopmental features. These findings are supported by an international&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-1301","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1301"}],"version-history":[{"count":23,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1301\/revisions"}],"predecessor-version":[{"id":2428,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1301\/revisions\/2428"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}