{"id":1299,"date":"2025-10-06T02:00:00","date_gmt":"2025-10-06T02:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=038ff6a39e9539182aa59dfec693a3b5"},"modified":"2025-10-06T23:00:00","modified_gmt":"2025-10-06T23:00:00","slug":"distinguishing-syndromic-and-nonsyndromic-cleft-palate-through-analysis-of-protein-altering-de-novo-variants-in-818-trios","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/10\/06\/distinguishing-syndromic-and-nonsyndromic-cleft-palate-through-analysis-of-protein-altering-de-novo-variants-in-818-trios\/","title":{"rendered":"Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 818 trios"},"content":{"rendered":"Cleft palate probands are globally enriched for protein-altering de novo variants, and gene-specific enrichment was found for seven cleft-related genes. Differences in individuals with syndromic versus nonsyndromic cleft palate were observed, although overlap in affected genes between groups suggests the existence of a phenotypic spectrum rather than distinct etiologies.","protected":false},"excerpt":{"rendered":"<p>Cleft palate probands are globally enriched for protein-altering de novo variants, and gene-specific enrichment was found for seven cleft-related genes. Differences in individuals with syndromic versus nonsyndromic cleft palate were observed, although &#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-1299","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1299"}],"version-history":[{"count":23,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1299\/revisions"}],"predecessor-version":[{"id":2427,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1299\/revisions\/2427"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}