{"id":1291,"date":"2025-10-13T02:00:00","date_gmt":"2025-10-13T02:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=10dff1b7ff79a9f59da591fac157ea45"},"modified":"2025-10-13T23:00:00","modified_gmt":"2025-10-13T23:00:00","slug":"a-scalable-framework-for-identifying-allelic-series-from-summary-statistics","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/10\/13\/a-scalable-framework-for-identifying-allelic-series-from-summary-statistics\/","title":{"rendered":"A scalable framework for identifying allelic series from summary statistics"},"content":{"rendered":"COAST-SS extends the coding-variant allelic series test to operate on summary statistics: per-variant effect sizes, standard errors, and local linkage disequilibrium (LD). COAST-SS controls the type I error, is robust to LD misspecification, and enables rapid genome-wide scans. We apply COAST-SS to identify lipid-trait allelic series in a meta-analyzed cohort of 840,000.","protected":false},"excerpt":{"rendered":"<p>COAST-SS extends the coding-variant allelic series test to operate on summary statistics: per-variant effect sizes, standard errors, and local linkage disequilibrium (LD). COAST-SS controls the type I error, is robust to LD misspecification, and enable&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-1291","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1291"}],"version-history":[{"count":23,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1291\/revisions"}],"predecessor-version":[{"id":2423,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1291\/revisions\/2423"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}