{"id":1283,"date":"2025-10-23T02:00:00","date_gmt":"2025-10-23T02:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=f8122023ee78cd662e84264957f84d6e"},"modified":"2025-10-23T23:00:00","modified_gmt":"2025-10-23T23:00:00","slug":"logica-a-likelihood-framework-for-cross-ancestry-local-genetic-correlation-estimation-using-summary-statistics","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/10\/23\/logica-a-likelihood-framework-for-cross-ancestry-local-genetic-correlation-estimation-using-summary-statistics\/","title":{"rendered":"Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics"},"content":{"rendered":"Logica estimates local cross-ancestry genetic correlation from genome-wide association study summary statistics via a bivariate linear mixed model that accounts for ancestry-specific linkage-disequilibrium structure. Across simulations and 13 traits from multi-ancestry biobanks, Logica delivers greater accuracy, power, and false-discovery-rate control and yields valid genome-wide estimates in regions where existing methods fail.","protected":false},"excerpt":{"rendered":"<p>Logica estimates local cross-ancestry genetic correlation from genome-wide association study summary statistics via a bivariate linear mixed model that accounts for ancestry-specific linkage-disequilibrium structure. Across simulations and 13 traits fr&#8230;<\/p>\n","protected":false},"author":259,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-1283","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/259"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1283"}],"version-history":[{"count":23,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1283\/revisions"}],"predecessor-version":[{"id":2419,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1283\/revisions\/2419"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}