{"id":1247,"date":"2025-08-25T00:00:00","date_gmt":"2025-08-25T00:00:00","guid":{"rendered":"https:\/\/www.annualreviews.org\/content\/journals\/10.1146\/annurev-genom-120523-024422?TRACK=RSS"},"modified":"2025-08-25T00:00:00","modified_gmt":"2025-08-25T00:00:00","slug":"the-genomics-of-aging-at-the-single-cell-scale","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/08\/25\/the-genomics-of-aging-at-the-single-cell-scale\/","title":{"rendered":"The Genomics of Aging at the Single-Cell Scale"},"content":{"rendered":"<div><p>Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellular changes that contribute to disrupted system homeostasis and increased vulnerability to age-related diseases. Despite the abundance of data generated over the past decade, a systematic understanding of how aging affects cell type&#8211;specific populations across the entire mammalian organism remains lacking&#8212;a critical gap for elucidating the cellular foundations of aging-related system dysfunction. In this review, we address this knowledge gap by summarizing recent single-cell studies examining the impact of aging on cell type&#8211;specific population changes across mammalian organs. We also review the impact of gender and anti-aging interventions on cell population dynamics in aged mammals. This work provides a comprehensive catalog of cellular states susceptible to aging, highlighting potential therapeutic targets for aging and age-related diseases.<\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated&#8230;<\/p>\n","protected":false},"author":246,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40,6],"tags":[87],"class_list":["post-1247","post","type-post","status-publish","format-standard","hentry","category-annual-review-of-genomics-and-human-genetics","category-articulos","tag-annurevgenomicshumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/246"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1247"}],"version-history":[{"count":1,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1247\/revisions"}],"predecessor-version":[{"id":1248,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1247\/revisions\/1248"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}