{"id":11377,"date":"2026-02-17T17:00:00","date_gmt":"2026-02-17T17:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=9e3ed2dcd7b7cb64ebb10d382f914133"},"modified":"2026-02-17T23:00:00","modified_gmt":"2026-02-17T23:00:00","slug":"multiple-testing-corrections-in-case-control-studies-using-identity-by-descent-segments","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/02\/17\/multiple-testing-corrections-in-case-control-studies-using-identity-by-descent-segments\/","title":{"rendered":"Multiple-testing corrections in case-control studies using identity-by-descent segments"},"content":{"rendered":"We developed an automated, reproducible, and scalable workflow to perform scans for disproportionate identity-by-descent sharing between cases and controls, determining well-controlled significance levels by modeling correlations along the genome. When applied to the Alzheimer\u2019s Disease Sequencing Project, our approach detected signals implicating therapeutic gene targets for Alzheimer disease.","protected":false},"excerpt":{"rendered":"<p>We developed an automated, reproducible, and scalable workflow to perform scans for disproportionate identity-by-descent sharing between cases and controls, determining well-controlled significance levels by modeling correlations along the genome. When&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-11377","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=11377"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11377\/revisions"}],"predecessor-version":[{"id":11469,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11377\/revisions\/11469"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=11377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=11377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=11377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}