{"id":11369,"date":"2026-02-23T17:00:00","date_gmt":"2026-02-23T17:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=1ce09e0c0f2f1ba1c6d8dbcf1e546586"},"modified":"2026-02-23T23:00:00","modified_gmt":"2026-02-23T23:00:00","slug":"bi-allelic-variants-in-nrdc-cause-a-neurodevelopmental-disorder-characterized-by-neonatal-lethality-microcephaly-and-brain-abnormalities","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/02\/23\/bi-allelic-variants-in-nrdc-cause-a-neurodevelopmental-disorder-characterized-by-neonatal-lethality-microcephaly-and-brain-abnormalities\/","title":{"rendered":"Bi-allelic variants in NRDC cause a neurodevelopmental disorder characterized by neonatal lethality, microcephaly, and brain abnormalities"},"content":{"rendered":"The study investigated the function of NRDC as a neurogenetic syndrome using a Drosophila model and affected individual-derived cells. Investigators from 10 different countries merged the efforts and identified 14 individuals with loss-of-function mutations in NRDC and presenting with severe neurodevelopment disorder and early lethality.","protected":false},"excerpt":{"rendered":"<p>The study investigated the function of NRDC as a neurogenetic syndrome using a Drosophila model and affected individual-derived cells. Investigators from 10 different countries merged the efforts and identified 14 individuals with loss-of-function muta&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-11369","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=11369"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11369\/revisions"}],"predecessor-version":[{"id":11465,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11369\/revisions\/11465"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=11369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=11369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=11369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}