{"id":11357,"date":"2026-03-05T17:00:00","date_gmt":"2026-03-05T17:00:00","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=d9c579cddf6151b3361e16561b62a327"},"modified":"2026-03-05T23:00:00","modified_gmt":"2026-03-05T23:00:00","slug":"mind-the-gap-characterizing-bias-due-to-population-mismatch-in-two-sample-mendelian-randomization","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2026\/03\/05\/mind-the-gap-characterizing-bias-due-to-population-mismatch-in-two-sample-mendelian-randomization\/","title":{"rendered":"Mind the gap: Characterizing bias due to population mismatch in two-sample Mendelian randomization"},"content":{"rendered":"We demonstrate that differences between populations can lead to biased causal effect estimates in Mendelian randomization (MR), a causal inference method based on genetic data. We provide a broad empirical survey of the size of these biases, demonstrating that bias can be substantial even when populations are considered close.","protected":false},"excerpt":{"rendered":"<p>We demonstrate that differences between populations can lead to biased causal effect estimates in Mendelian randomization (MR), a causal inference method based on genetic data. We provide a broad empirical survey of the size of these biases, demonstrat&#8230;<\/p>\n","protected":false},"author":469,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,41],"tags":[48],"class_list":["post-11357","post","type-post","status-publish","format-standard","hentry","category-articulos","category-the-american-journal-of-human-genetics","tag-amjhumgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/469"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=11357"}],"version-history":[{"count":24,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11357\/revisions"}],"predecessor-version":[{"id":11459,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/11357\/revisions\/11459"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=11357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=11357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=11357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}