{"id":1047,"date":"2025-11-09T17:00:22","date_gmt":"2025-11-09T17:00:22","guid":{"rendered":"http:\/\/sebigec.es\/blog\/?guid=a1aa98f82b09e02ee5800e38b8c26696"},"modified":"2026-01-20T14:16:17","modified_gmt":"2026-01-20T14:16:17","slug":"specific-considerations-for-mutyh-carrier-testing-in-individuals-of-gujarati-heritage-uk-cancer-genetics-group-recommendations","status":"publish","type":"post","link":"https:\/\/sebigec.es\/blog\/index.php\/2025\/11\/09\/specific-considerations-for-mutyh-carrier-testing-in-individuals-of-gujarati-heritage-uk-cancer-genetics-group-recommendations\/","title":{"rendered":"Specific considerations for MUTYH carrier testing in individuals of Gujarati heritage: UK cancer genetics group recommendations"},"content":{"rendered":" <p><I>MUTYH<\/I>-associated polyposis (MAP) is an autosomal recessive cancer predisposition syndrome. Gujarati heritage is enriched in patients with MAP. Endogamy is frequent in this community. Among ethnicity-matched participants of the 100 000 Genomes Project, the frequency of recurrent pathogenic <I>MUTYH<\/I> variants in most populations is rarer than that at which testing of reproductive partners of carriers is usually considered. However, <I>MUTYH<\/I> c.1438G&gt;T (p.Glu480Ter) in participants of Gujarati heritage is relatively common (~1 in 75). We recommend targeted testing for partner(s) of a carrier of <I>MUTYH<\/I> variant(s) if of Gujarati heritage, to inform reproductive decision-making\/management of children. Existing UKCGG guidance is unchanged for other populations.<\/p> <p>In the UK, testing of reproductive partners (&lsquo;partner testing&rsquo;) of carriers of recessive traits or individuals affected by recessive disorders is rarely indicated, but may be required in certain circumstances, where there is a relatively high likelihood of having a child affected by a recessive condition&mdash;that is,...","protected":false},"excerpt":{"rendered":"<p> MUTYH-associated polyposis (MAP) is an autosomal recessive cancer predisposition syndrome. Gujarati heritage is enriched in patients with MAP. Endogamy is frequent in this community. Among ethnicity-matched participants of the 100 000 Genomes Project,&#8230;<\/p>\n","protected":false},"author":221,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,14],"tags":[83],"class_list":["post-1047","post","type-post","status-publish","format-standard","hentry","category-articulos","category-jmg","tag-jmedgenet"],"_links":{"self":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/users\/221"}],"replies":[{"embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=1047"}],"version-history":[{"count":2,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1047\/revisions"}],"predecessor-version":[{"id":6819,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/posts\/1047\/revisions\/6819"}],"wp:attachment":[{"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=1047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=1047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sebigec.es\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=1047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}