Etiqueta: #TrendsGen

Recent studies have reported that catalytically dead histone-modifying enzymes can rescue the function of their null alleles. Histone ‘replacement’ experiments have similarly found a lack of phenotypes for some modifications. Do these findings foretell…

Gene activity is intricately shaped by its chromatin environment. Deciphering the chromatin landscape is essential for understanding the complex regulatory networks governing gene function. The newly re-recognized DNA N6-methyladenine (6mA) is relative…

The power of short-read DNA sequencing in biodiversity research and evolutionary genomics is rapidly growing due to advances in technology and bioinformatics. Short-read sequencing offers powerful solutions for taxonomic identification, biomass estimat…

When this article was first published, relevant funding information was inadvertently omitted. An Acknowledgments section with the funding information, as shown later, has now been added to the original article. The authors apologize for the unintentio…

Transposable elements (TEs) – long considered ‘junk DNA’ – challenge the binary of threat and therapeutic opportunity in cancer. Their reactivation is not a singular event but a convergence of evolutionary legacy, regulatory disruption, and technologic…

Complex diseases are heterogeneous and evolve along a continuum, limiting individual-level prediction with current approaches. The Human Phenotype Project (HPP) integrates deep phenotyping with generative artificial intelligence (AI) to identify early …

Interruptions within expanded tandem repeats reduce somatic expansion and alter the severity of the resulting diseases. Consequently, much has been done to identify interruptions in the human population and assess their clinical impact. However, how in…

The current nomenclatural rules regulating the naming of microorganisms are too conservative from the perspective of recent developments in molecular genetics tools and organism discovery. The taxonomy of microorganisms would greatly benefit from a con…

Despite decades of clubroot research, only three resistance (R) genes have been validated. However, many of the ‘new’ R genes are, in fact, identical to or allelic with these three. In this forum article we advocate for more concerted efforts to reduce…

The genome is packaged with nuclear proteins and RNAs into a complex structure known as chromatin. Its dynamic organization influences genome functions and nuclear properties. Since 2009, high-throughput DNA sequencing methods such as Hi-C and ChIA-PET…