Etiqueta: AmJHumGenet
-
Systematic identification of genotype-dependent enhancer variants in eosinophilic esophagitis
Shook et al. developed and applied a massively parallel reporter assay for the allergic disease eosinophilic esophagitis (EoE). They identified common polymorphisms associated with EoE risk that also impacted transcriptional regulation. This study is a…
-
A Bayesian fine-mapping model using a continuous global-local shrinkage prior with applications in prostate cancer analysis
We develop a fine-mapping method, called h2-D2, utilizing a continuous global-local shrinkage prior, and propose an approach to define credible set of causal variants in this framework. Our proposed method outperforms the state-of-art fine-mapping meth…