Categoría: Trends in Genetics

Small nucleolar RNAs (snoRNAs), traditionally regarded as guides for RNA modification, have emerged as critical regulators of tumor progression and treatment resistance. This review comprehensively outlines the roles of snoRNAs and their host genes in …

As the field of spatial omics continues to expand, the spatially resolved profiling of microRNA (miRNA) expression in tissues, or ‘spatial miRNomics,’ remains in its infancy, with only a few initial pioneering studies to date. MiRNA expression exhibits…

Small nuclear ribonucleoproteins (snRNPs) U1/U2/U4/U6 are critical constituents of the spliceosome. Recent studies showed that each of them exhibits a role in the inhibition of global PCPA (premature cleavage and polyadenylation), thereby supporting th…

N6-methyladenosine (m6A) is the most abundant internal modification in mRNA and plays a crucial role in regulating mRNA turnover. This review explores the characteristics of m6A sites in the coding sequence (CDS) and their influence on mRNA decay, with…

Clitellate genomes are the result of a profound genome reshaping compared to marine annelids, as if their genomes had exploded into thousands of atomic pieces and were reassembled in a different order by evolution. Recent studies not only revealed wide…

The concurrent processes of DNA replication and RNA transcription pose a significant challenge to genome integrity. Nascent RNA, the newly synthesized transcript, is emerging as a critical determinant of transcription–replication conflict (TRC) outcome…

For 35 years, the Ethical, Legal, and Social Implications (ELSI) Research Program has addressed the societal implications of genomic research. However, its policy impact remains controversial. Here, we propose practical approaches for enhancing its pol…

Investigating RNA dynamics is crucial for uncovering fundamental mechanisms, such as alternative splicing, RNA stability, and post-transcriptional modifications, all processes with implications for identifying therapeutic targets and advancing knowledg…

Due to its high variation and its diversity of functional roles, animal colouration has long been a fascinating phenotype for geneticists. While the loci underpinning colour are relatively well known, there remain components of unexplained variation. T…

Variation of mutation rates between species has been documented over decades, but the variation between different regions of a genome has been less often discussed. Recent studies using high-quality sequence data have revealed previously unknown levels…