Categoría: Trends in Genetics

Interruptions within expanded tandem repeats reduce somatic expansion and alter the severity of the resulting diseases. Consequently, much has been done to identify interruptions in the human population and assess their clinical impact. However, how in…

The current nomenclatural rules regulating the naming of microorganisms are too conservative from the perspective of recent developments in molecular genetics tools and organism discovery. The taxonomy of microorganisms would greatly benefit from a con…

Despite decades of clubroot research, only three resistance (R) genes have been validated. However, many of the ‘new’ R genes are, in fact, identical to or allelic with these three. In this forum article we advocate for more concerted efforts to reduce…

The genome is packaged with nuclear proteins and RNAs into a complex structure known as chromatin. Its dynamic organization influences genome functions and nuclear properties. Since 2009, high-throughput DNA sequencing methods such as Hi-C and ChIA-PET…

Over the past decade, single-cell omics sequencing technologies have revolutionized biological and medical research and deepened our knowledge of cellular heterogeneities in life activities at the genomic, epigenomic, and transcriptomic levels. Concurr…

Z-DNA is a left-handed alternative DNA structure that forms at alternating purine-pyrimidine repeats, which are abundant in genomes. It is intrinsically unstable under physiological conditions; however, it can be stabilized by negative supercoiling and…

The brain’s complexity arises from diverse cell types varying spatially and temporally. N6-methyladenosine (m6A), the most abundant mRNA modification, regulates gene expression and cellular function. While bulk sequencing studies have provided foundati…

How do new species arise? This is among the most fundamental questions in evolutionary biology. The first genetic model for how reproductive barriers lead to the origin of new species was proposed nearly 90 years ago. However, empirical evidence for th…

Boundaries of cross-kingdom RNA communication are now being expanded, with recent work showing that plants deliver gene-silencing RNA into bacteria. Ravet et al. report that both extracellular vesicular and nonvesicular RNAs are biologically active, ch…

Genomic landscapes of introgression provide valuable information on how different evolutionary processes interact and leave signatures in genomes. The recent expansion of genomic datasets across diverse taxa, together with advances in methodological de…