Categoría: Trends in Genetics

Symbiosis is a fundamental characteristic of eukaryotic biology. Arthropods, including insects, often harbor maternally inherited endosymbiotic microbes, some of which have evolved the ability to selectively kill male hosts – a phenomenon known as ‘mal…

Germ cell development involves extensive remodeling of the 3D genome architecture, which is tightly coupled to transcriptional programs, meiotic chromosome dynamics, and re-establishment of totipotency in the next generation. Recent advances in chromos…

Beyond their degradative role, lysosomes help prepare Caenorhabditis elegans offspring for stress. In a recent study, Zhang et al. show that lysosomal activation induces somatic histone H3.3 production, which moves to the germline and is methylated at …

Autism genetics research has the capacity to improve the quality of life of autistic community members, but research priorities vary widely across stakeholders. We summarize key points from our discussion series on autism genetics, highlighting diverse…

Circular RNAs (circRNAs) are natural outputs of transcription and RNA processing in eukaryotes. Four subclasses of circRNAs have been identified in animal cells, and most circRNAs are generated via backsplicing. The intricate formation of circRNAs is o…

AlphaGenome, recently announced in a preprint by Avsec et al., is Google DeepMind’s powerful ‘Swiss army knife’ for predicting molecular effects from non-coding DNA. Remarkably, it does so with base-pair resolution while maintaining long-range context….