Categoría: Trends in Genetics
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Medaka: a novel model for analyzing genome–environment interactions
Medaka is an established vertebrate model system for biological and biomedical research. It possesses unique features that make it particularly suitable for studying genome–environment interactions. Endemic to habitats spanning from 4 to 40°C and varyi…
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Beyond the ‘one nucleus, one whole genome’ rule
The ‘one nucleus, one whole genome’ rule has long defined nuclear organization in eukaryotes. Three fungi were recently uncovered to separate their haploid chromosomes into different nuclei, revealing an unexpected nuclear dimension. Here, we discuss h…
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Uncovering layers of mutation in plant stem cells
How are new mutations kept from accumulating in a germline that is specified late in the plant life cycle? Amundson et al. (2025) reported that the accumulation of mutations in plant stem cells is tissue layer specific and the layered architecture of t…
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Evolutionarily conserved regulation and functions of H1 linker histones in development
Linker histone H1 is a fundamental chromatin component, essential for higher-order chromatin compaction and transcriptional regulation. Chromatin regulator associated with M phase protein 1 (CRAMP1) was recently identified as a highly conserved factor …
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Reproductive phasiRNAs are the piRNAs of plants
Small RNAs are fundamental to gene expression regulation, with specialized classes playing critical roles in reproduction. This review compares animal PIWI-interacting RNAs (piRNAs) and plant reproductive phased small interfering RNAs (phasiRNAs), whic…
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Gene sharing has stabilised the genetic code
The genetic code is nearly universal across life. Yet, The National Center for Biotechnology Information (NCBI) genetic code table recognises 27 distinct variants, most of which are confined to eukaryotic nuclei and organelles. Comparative genomics and…
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Salutogenomics: embracing the full spectrum of human health
Modern biomedical genomics has principally centered on disease, leveraging genomic insights to identify disease-associated genotypes. While valuable, this approach is overly reliant on a positivist, disease-centric perspective that often goes hand-in-h…
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Gene expression noise in development: genome-wide dynamics
Gene expression noise underlies cell-to-cell variability in RNA and protein levels of a seemingly homogeneous population of cells. Emerging evidence suggests a functional role for this variability in the specification of cell fates during mammalian dev…