Categoría: Trends in Genetics

The concept of extended phenotypes – the effects of genes outside of an individual organism – was formulated by the evolutionary biologist Richard Dawkins over 40 years ago. Driven by modern molecular tools and interdisciplinary perspectives, the study…

Transcription is not only an essential cellular process but also a major source of endogenous DNA strand breaks. Many cancers exhibit transcriptional addiction and rely on dysregulated and excessive transcription to maintain the malignant state. We rev…

Researchers often assume genomic results are too complex for lay communities, but heredity concepts are widely understood. Effective return of results depends on cultural context, clear communication, and collaboration with communities. Tailored, respe…

The DNA mismatch repair (MMR) system is classically viewed as being anti-recombinogenic during meiosis because it mediates heteroduplex rejection to inhibit homeologous recombination, leading to postzygotic isolation between closely related species. In…

Twenty-five years after the histone code hypothesis proposed that combinations of histone post-translational modifications (PTMs) direct gene regulation, fundamental questions remain unresolved. Here, I outline a call for a multi-laboratory initiative,…

Public interpretations of genetic science in popular media shape its meaning, regulation, and sometimes even its trajectory. Drawing on examples from film and television, we argue that cultural narratives are not merely reflections of science but activ…

De-extinction critiques focus on animal welfare, ecosystem disruption, threats to traditional conservation, and anxiety about human hubris. Respondents argue that humanity is obligated to reverse damage to species (natural or human-caused) and to pursu…

Genomics research has historically been biased toward individuals of European ancestry, which has the potential to exacerbate health inequities (Martin, A.R. et al.) To reduce these disparities, current efforts in human genetics emphasize the inclusion…