Categoría: ScienceDaily
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This One Microglia Mutation Could Triple Your Alzheimer’s Risk – Here’s Why
A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation, and contribute to Alzheimer’s pathology in other ways. A rare but potent genetic mutation that alters a protein in the brain’s immune cells, known as microglia, can give people as much as a threefold greater risk of developing Alzheimer’s disease. A…
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Unlocking the human genome: Innovative machine learning tool predicts functional consequences of genetic variants
Model accelerates genetic research toward more tailored treatments Date:December 14, 2023Source:The Mount Sinai Hospital / Mount Sinai School of MedicineSummary:In a novel study, researchers introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome. Unlike current methods that predominantly focus on loss of function, LoGoFunc distinguishes among different types…