Categoría: Neuroscience
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Understanding the path from genetic changes to Parkinson’s disease opens possibilities for early diagnosis
A team led by researchers at Baylor College of Medicine and the Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital has uncovered a chain of events that connects genetic alterations, disruptions in lipid metabolism and the …
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Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents
A University of Calgary-led international research team has identified a genetic factor that may explain why people respond so differently to opioid pain medications, and why some individuals face greater risk of side effects including dependency. The …
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Examining DNA molecules one by one: How combining techniques can help us understand diseases such as dementia
«By cleverly combining new techniques for analyzing DNA at the level of individual molecules, we can achieve real breakthroughs in research into conditions such as dementia,» predicts Professor John van Noort. Together with four leading biophysics rese…
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It takes two: Genes ATP13A2 and GBA1 interact to drive neurodegeneration
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting more than 10 million people worldwide. People with this condition may experience tremors, limb stiffness, gait and balance problems and mo…
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Protective mechanism discovered in female brain: Switched-off X chromosome can reactivate to reduce disease severity
Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have identified a mechanism that protects the female brain from genetic diseases. Although one of the two X chromosomes is switched off in female cells at an early stage, cells reac…
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RNA therapy may be a solution for infant hydrocephalus
Hydrocephalus is a life-threatening condition that occurs in about 1 in 1,000 newborns and is often treated with invasive surgery. Now, a new study offers hope of preventing hydrocephalus before it even occurs. The paper is published in the journal Mol…
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Two-year-old’s medical care was transformed by research that connected her epilepsy to heart conditions
Two minutes. That’s how long two-year-old Briar Curtis’s heart stopped during a severe seizure in April 2025. Since birth and before, Briar had been sick. Her heart rate in the womb was high and erratic.
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Early neural stem cell defects in Leigh syndrome may help children get diagnosed sooner
Virginia Tech researchers have discovered an indication hidden in the brain that may help doctors identify children suffering from a rare genetic disease earlier. Their findings are published in EMBO Molecular Medicine.
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A curiosity-driven journey toward understanding brain folding
The human brain’s soft folds and ridges, arising in early development and continuing through the first 18 months of life, are a visual icon for intelligence itself. Peeling back the layers of this fundamental biological process has been a long-sought g…
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Rare cranial disorders: Towards a non-invasive therapy using gene silencing delivered by nanoparticles and 3D printing
A «gene silencer» (technically known as small interfering RNA, or siRNA), locally delivered by nanoparticles embedded in an injectable gel produced through 3D printing, can switch off the defective gene responsible for serious rare diseases known as cr…