Categoría: Genetics
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AI-built maps reveal causal gene regulation across Alzheimer’s brain cell types
Researchers led by Min Zhang and Dabao Zhang of the University of California, Irvine’s Joe C. Wen School of Population & Public Health have created the most detailed maps to date showing how genes causally regulate one another across different types of…
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Study reveals the gene networks driving sex differences in respiratory health
A new study has confirmed that male and female lungs are «wired differently» at the molecular level, providing further evidence supporting sex-inclusive respiratory disease research and treatment. The work is published in The FASEB Journal.
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From bench to bedside—research in mice leads to answers for undiagnosed human neurodevelopmental conditions
Nearly 30 years ago, researchers began studying the gene Astn1, which encodes the cell adhesion protein astrotactin 1 in mice, and its role in brain development. During this time, they learned a great deal about the function of astrotactin 1 in neurona…
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Growth of spreading pancreatic cancer is fueled by ‘underappreciated’ epigenetic changes, shows study
In a lab-grown cell study focused on potential new treatment targets for halting the spread of most pancreatic cancers, Johns Hopkins Medicine scientists report they have found that a gene called KLF5 (Krueppel-like factor 5) fuels the growth of such s…
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Review of 40 years of genetics suggests dyslexia involves broader brain networks
A University of Houston psychology professor is challenging the notion that dyslexia, or specific reading disorder, stems from a single faulty gene in the brain, suggesting instead that it is caused by an overall brain network vulnerability. The insigh…
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Genetic testing in sports: Fairness, human rights and the law
Testing the biological sex of an athlete is becoming more common in sport, with governing bodies defending the practice as safeguarding fairness for women. But as the introduction of mandatory genetic testing raises questions about human rights, it cou…
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What a new twins study reveals about genes, environment and longevity
Why do some people live to 100 while their sibling dies decades earlier? Is it luck, lifestyle, or something written into their DNA? Relative to many other species, humans are particularly long-lived, but there is an ongoing argument about how much of …
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Genetic study shows that anxiety disorders have many causes
About 1 in 4 people suffer from an anxiety disorder at some point in their lives. These include panic disorder with sudden, severe anxiety attacks; generalized anxiety disorder, in which sufferers worry about everyday things over a longer period of tim…
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MDGA2 gene malfunction removes brain’s excitatory ‘brake’ to trigger severe epilepsy, study finds
The DGIST Center for Synapse Diversity and Specificity has identified MDGA2 as a novel causative gene for developmental and epileptic encephalopathy (DEE), a rare and intractable neurological disorder occurring in infancy and early childhood. This stud…
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‘Celtic curse’ genetic disease hotspots revealed in UK and Ireland
People from the Outer Hebrides and north-west Ireland have the highest risk of developing a genetic disease that causes a dangerous build-up of iron in the body, a study published in the journal Nature Communications suggests.