Autor: Yanyu Liang, Festus Nyasimi, Hae Kyung Im
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A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies
We show that transcriptome-wide association studies (TWAS) and related methods (xWAS) using genetic predictors suffer from inflated false-positive rates for highly polygenic complex traits, increasing linearly with sample size and heritability. We prop…