Autor: Xinjun Wang, Caroline Kostrzewa, Allison Reiner, Ronglai Shen, Colin Begg
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Adaptation of a mutual exclusivity framework to identify driver mutations within oncogenic pathways
Cancer is known to arise after a cell experiences multiple driver mutations that allow it to grow uncontrollably and ultimately metastasize to distant anatomic sites. In this paper, we introduce a computational approach for identifying driver mutations…