Autor: Shemesh, S., Bernstein-Molho, R., Shoval, S., Laitman, Y., Madorsky-Feldman, D., Friedman, E., Elkon, R.
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Damaging missense variants in innate immunity genes are associated with earlier age of breast cancer onset in BRCA1 185delAG carriers
BackgroundPenetrance of breast cancer (BC) among women who carry pathogenic variants (PVs) in BRCA1 is incomplete, and the age at BC diagnosis varies considerably, even among carriers of the same PV, suggesting the involvement of genetic and non-geneti…