Autor: Nan Chen, Jingjing Feng, Dong Wan, Dongbing Li, Sheng Xiao
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Enhanced Detection of EGFRvIII in Tumors: A Comparative Study of Split Read and Read Depth-Based DNA Sequencing Approaches
Epidermal Growth Factor Receptor variant III (EGFRvIII), a common oncogenic variant in glioblastoma (GBM) and other solid tumors, results from an in-frame deletion of exons 2–7 in the EGFR gene. Detection of EGFRvIII is crucial for understanding tumor …