Autor: Lisa Robinson, Sharleen Rapp, Weiwei Zhang, Jaclyn Pope, Allison M. Cushman-Vokoun
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Dideoxy sequencing enhances detection of KIT mutations in GISTs initially evaluated by NGS hotspot panels
GISTs are predominantly characterized by mutations in KIT or PDGFRA. Mutation detection is important for optimal therapy. NGS panels are useful in GIST assessment as they allow for simultaneous evaluation of multiple genes. However, inherent to use of …