Autor: Hong-Yu Li, Yuying Shen, Keng Ioi Vong, Kristopher T. Kahle, Joseph G. Gleeson
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De novo mutations and environmental modifiers: lessons from neural tube defects
Spina bifida is a clinically and etiologically heterogeneous group of neural tube defects (NTDs) that includes meningomyelocele. While folic acid (FA) supplementation has reduced the incidence by 30–50%, genetic contributors remain only partially under…