Diagnostic utility of SNPM microarray in evaluating pancreaticobiliary brushing specimens in conjunction with conventional cytology

Bile duct brushings are non-invasive sampling of cells from the biliary tract for cytological evaluation and are useful to diagnose pancreaticobiliary malignancies. Although specificity of cytology is satisfactory, sensitivity is inherently low due to challenging or absent morphological features. Utilizing molecular markers by incorporating FISH has significantly improved sensitivity and diagnosis. To further advance the use of molecular markers, we have employed OncoScan microarray, which has genome-wide coverage and significantly higher resolution compared to FISH.