Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman

Genomic analyses of Omani blood donors reveal a high frequency of the FyES allele at the Duffy locus, accompanied by elevated African ancestry. These alleles were likely introduced via early African admixture and rose in frequency through positive selection. These findings may help explain regional variation in Plasmodium vivax prevalence.