Expanded chromatin accessibility mapping explains genetic variation associated with complex traits in liver

We performed chromatin accessibility quantitative trait locus (caQTL) mapping in 175 healthy human liver samples and identified 14,076 caQTLs. These data, along with other regulatory mechanism datasets, were integrated with liver-relevant genome-wide association study (GWAS) signals, such as blood lipids, to propose mechanisms for approximately 80% of signals.